c. 316 BCE
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316 BCE: Thessalonica is founded by Cassander.
168 BCE: Thessalonica comes under Roman control.
146 BCE: Thessalonica is made the captial of the Roman province of Macedon.
250 CE: Thessalonica is made a Roman colony.
298 CE: Galerius builds a triumphal arch at Thessalonica.
305 CE: Roman emperor Galerius makes Thessalonica his official residence.
550 CE: The Slavs advance towards Thessalonica, entering the region of the Hebrus River and the Thracian coast. Thessalonica is saved by the Roman army.