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507 BCE: Artaphernes receives envoys from Athens who seem to promise submission to the Achaemenid Empire; an event which affects later Greco-Persian relations.
260 BCE - 195 BCE: King Euthydemus I of the Greco-Bactrian Kingdom rules in Central Asia.
250 BCE: Former satrap Diodotos rebels against Seleucid king Antiochos I, creating the Greco-Bactrian kingdom.
230 BCE: Diodotos II is overthrown by Euthydemos. Beginning of the Euthydemid dynasty.
208 BCE - 206 BCE: Siege of Bactra by Antiochos III.
208 BCE: Seleucid king Antiochos III wins the battle of the Arius river against Euthydemos.
206 BCE: Recognition of the Greco-Bactrian kingdom and Euthydemid dynasty by Antiochos III.
200 BCE: Beginning of the Greco-Bactrian conquests in India.
200 BCE: First contact between China and the Greco-Bactrian descendents of Alexander the Great's army.
190 BCE: First appearance of multiple Euthydemid kings at the same time. Beginning of the Indo-Greek kingdoms.
186 BCE: Demetrios wins a decisive battle in Gandhara, beginning the Yona (or Greek era) in India.
171 BCE: Eucratides begins his uprising against Greco-Bactrian king Demetrios II.
171 BCE: In odrer to show the break of dynasty, Eucratides begin a new Yona (or Greek) era.
165 BCE: The Greco-Bactrian king Eucratides invades India.
155 BCE: The Euthydemid Menander succeeds to push back the Eucratids westward of the Hindu-Kush.
145 BCE: Murder of Eucratides by his son. Weakening of the Greco-Bactrian kingdom.
130 BCE: The Yuezhei take control of Bactria.