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437 BCE: Athens founds the colony of Amphipolis in northern Macedonia.
364 BCE: Macedonian general Perdikkas III successfully defends Amphipolis against Athenian attack.
359 BCE - 336 BCE: Reign of Philip II of Macedon.
359 BCE: Phillip II takes throne of Macedonia.
357 BCE: Marriage of Olympias to Philip II of Macedonia.
356 BCE: Birth of Macedonian commander Hephaestion.
343 BCE: King Philip II of Macedon summons Aristotle to tutor his young son Alexander (later 'The Great').
339 BCE: Philip II of Macedon fights the Scythians.
336 BCE: Marraige of Olympias' brother Alexander to her daughter Cleopatra.
324 BCE: Death of Macedonian commander Hephaestion.
319 BCE: Death of Antipater, regent of Macedonia.
317 BCE: Death of Olympias, mother of Alexander the Great.
310 BCE: Assassination of Roxanne and Alexander IV, wife and son of Alexander the Great.
225 BCE: Macedonians bring an army across the Isthmus to face another Achaian force trying to take Corinth.
214 BCE - 205 BCE: First Macedonian War: Rome defeats Philip V of Macedon.
203 BCE: The Seleucid king, Antiochus III Megas signs an alleged treaty with Philip V of Macedon to divide Egypt and its overseas possessions between them.
200 BCE - 196 BCE: Second Macedonian War: Roman victory.
197 BCE: Romans are victorious over Philip V of Macedon at Cynoscephalae.
172 BCE - 168 BCE: Third Macedonian War: Perseus of Macedon challenges Rome and is defeated.
168 BCE: Romans defeat Perseus of Macedon at Pydna.
150 BCE: Macedonia becomes a Roman province.