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813 BCE: Carthage is founded by Phoenicians.
580 BCE - 376 BCE: Carthage and Greece fight for dominance in Sicily.
539 BCE: Etruscan & Carthaginian alliance expels the Greeks from Corsica.
535 BCE: Battle of Alalia. Carthaginian navy, in alliance with Etruscans, defeated Greek ships off the island of Corsica.
500 BCE: Carthage expands into southern Spain.
480 BCE: Tyrant of Syracuse Gelon defeats the Carthaginians at the battle of Himera.
480 BCE: Agrigento defeats Carthage at the battle of Himera.
406 BCE: Agrigento is attacked and destroyed by Carthage.
405 BCE: Segesta comes under Carthaginian control.
396 BCE: The Carthaginian city of Lilybaeum is founded on Sicily.
264 BCE - 241 BCE: First Punic War. Carthage cedes Sicily to Rome.
263 BCE: Antaros and 3000 Celts fight with Carthage in the First Punic War.
260 BCE: Rome builds its first significant naval fleet in response to the threat from Carthage.
249 BCE: Antaros withdraws his support from Carthage.
249 BCE: A Roman fleet is defeated by the Carthaginians at Drepna.
248 BCE - 182 BCE: Life of Hannibal.
241 BCE - 238 BCE: The rebellion of the mercenaries: Unpaid mercenaries under the leadership of Mathos and Spendios rebel against Carthage. Despite a peace treaty, Rome seizes the opportunity to strip Carthage of Sardinia and Corsica.
218 BCE - 201 BCE: Second Punic War. Hannibal leads 50,000 foot soldiers, 9000 cavalry, and 37 war elephants over the Pyrennees and the Alps.
217 BCE: Victory of Hannibal over the Romans at Lake Trasimene.
216 BCE: Battle of Cannae. Worst defeat in Roman history, against Carthage.
216 BCE: "Hannibal ante portas." Hannibal directly threatens the city of Rome, but cannot advance due to lack of supplies and reinforcements.
212 BCE: The Romans conquer Saguntum from the Carthaginians.
207 BCE: Battle of Metaurus. Carthage loses against Rome and loses control of Iberia (Spain).
206 BCE - 205 BCE: The Romans conquer Gades. End of the Carthaginian presence on the Iberian Peninsula.
205 BCE: Scipio Africanus invades Africa to defeat Carthage.
204 BCE: Scipio Africanus sails over to Africa.
202 BCE: Battle of Zama. The Carthaginian army is defeated, Hannibal flees to Hadrumentum.
195 BCE: Facing the threat of being handed to the Romans as a result of the opposition to the reforms he initiated in Carthage, Hannibal flees to Crete and then to Tyre, in Seleucid territory. He will become one of the military advisors of king Antiochos III Megas in his war against Rome.
183 BCE: As an ambassador to the Hellenistic kingdom of Bithynia, T. Quinctius Flamininus, the general who defeated Macedon, demands that Hannibal should be surrendered in Roman hands. As king Prusias gives in, Hannibal commits suicide in the village of Libyssa, in order to escape captivity. The Roman Senate did not approve of Flamininus' action.
149 BCE - 146 BCE: Third Punic War.
146 BCE: End of the Third Punic War. Carthage is destroyed and its lands become the Roman province Africa.
162 CE: The Antonine Baths at Carthage are completed.