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321 BCE - 315 BCE: Seleucos rules the satrapy of Babylon.
312 BCE: Seleucos conquers Babylon and founds the Seleucid dynasty.
312 BCE: Evagros is killed in battle by Seleucos I. Persis comes under Seleucid rule.
305 BCE: Emperor Changragupta signs a treaty with Seleucus, establishing borders and giving the Punjab to Changragupta in return for 500 war elephants.
304 BCE - 64 BCE: Rule of the Seleucids in Mesopotamia.
301 BCE: Battle of Ipsos. Death of Antigonos, rise to power of Lysimachos and Seleucos.
301 BCE - 299 BCE: Antioch was founded by Seleucos I Nikator.
275 BCE: Seleucids successfully defeat the Galatian Celts in the 'Elephant Battle'.
274 BCE - 271 BCE: The first Syrian war, marking the beginning of the contest between the Ptolemies and the Seleucids for Phoenicia and Coele-Syria.
262 BCE: Eumenes rebels and wins against the Seleucid Antiochos I. Beginning of the Pergamon Empire.
261 BCE: Antiochus, king of the Seleucid empire, is killed in battle against the Galatians at Ephesus in Asia Minor.
250 BCE: Former satrap Diodotos rebels against Seleucid king Antiochos I, creating the Greco-Bactrian kingdom.
246 BCE: Galatians defeat Seleucus II in a battle near Ancyra.
210 BCE - 204 BCE: Anabasis of Antiochos III in the East.
203 BCE: The Seleucid king, Antiochus III Megas signs an alleged treaty with Philip V of Macedon to divide Egypt and its overseas possessions between them.
195 BCE: After the battle at Panion, the Seleucids finally take the rule of Phoenicia from the Ptolemies. Tyre and the other Phoenician cities will remain in the Seleucid power until the Roman conquest of Syria.
195 BCE: Facing the threat of being handed to the Romans as a result of the opposition to the reforms he initiated in Carthage, Hannibal flees to Crete and then to Tyre, in Seleucid territory. He will become one of the military advisors of king Antiochos III Megas in his war against Rome.
190 BCE: Battle of Magnesia ad Sipylum, disastrous defeat for Antiochos III against Romans.
189 BCE: The treaty of Apameea Kibotos. Peace and alliance is established between the Seleucid Kingdom and Rome joined by her allies, such as Pergamon and Rhodes. The Seleucids have to evacuate all the land and the cities from Asia Minor and to pay a huge war indemnity.
141 BCE: Persis passes from Seleucid to Parthian domination.
83 BCE: Tigranes II invades and destroys the Seleucid Empire.
64 BCE: The Roman general Pompey defeats the Seleucid Antiochus XIII and incorporates Syria as a province of the Roman empire.
190 CE: Side freed from Seleucid control.