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9000 BCE: Wild sheep flocks are managed in the Zagros mountains.
9000 BCE: Cultivation of wild cereals in the Fertile Crescent.
7700 BCE: First domesticated wheats in the Fertile Crescent.
6500 BCE: Cultivation of peas in the Eastern Mediterranean.
4300 BCE: The rise of the cities by the Tigris and Euphrates Rivers.
3500 BCE: Image of the breed of dog, the Saluki, appears on ceramics as household pet.
2334 BCE - 2279 BCE: Sargon of Akkad (the Great) reigns over Mesopotamia and thus creates the world's first empire.
2300 BCE: Wide spread production and use of soap.
2000 BCE: Domesticated horses introduced in Mesopotamia.
2000 BCE: Babylon controls Fertile Crescent.
1984 BCE: Amorite dynasty established in Babylon.
1900 BCE: Ashur, capial of Assyria, is founded.
1900 BCE - 1400 BCE: Trade flourishes between Mesopotamia and other regions.
1795 BCE - 1750 BCE: Reign of Hammurabi, king of Babylon.
1787 BCE: Hammurabi of Babylon conquers Uruk and Isin.
1772 BCE: The Code of Hammurabi: One of the earliest codes of law in the world.
1761 BCE: Hammurabi of Babylon destroys the city of Mari.
1680 BCE: Hurrians occupy Assyria.
1595 BCE: King Mursilis of the Hittites sacks Babylon. Begin of Babylonian "dark ages."
1550 BCE: Kingdom of Mittani is founded.
1500 BCE: Egyptian empire extends to the Euphrates.
1472 BCE: Mittani annexes Assyria.
1400 BCE: Assyria regains its independence.
1350 BCE - 1250 BCE: The Hittite empire is at its peak.
1321 BCE: Western Mittani is conquered by the Hittites.
1285 BCE: Peak of Hittite power.
1220 BCE: Babylon is under Assyrian control.
1200 BCE: Phrygians invade Anatolia and destroy the Hittite empire.
1080 BCE: Aramaeans invade Mesopotamia.
1000 BCE: Chaldeans occupy Ur.
853 BCE: Babylonian kings depend on Assyrian military support.
734 BCE: Babylon is captured by Chaldeans.
729 BCE: Babylon is occupied by Assyrians.
722 BCE - 705 BCE: Peak of the Assyrian empire under the reign of Sargon II.
600 BCE: Assyrians control the Fertile Crescent.
539 BCE: Cyrus the Great conquers Babylon; the Fertile Crescent is controlled by the Achaemenid Empire (The First Persian Empire).
334 BCE: Alexander the Great invades and conquers the Fertile Crescent.
116 CE: Invasion and annexation of the Fertile Crescent region by Rome under Trajan.